Theres also a memantine powder vendor on reddit, with great prices. But it is very pleasant sleep. A psychonaut is a person who experiences intentionally induced altered states of consciousness and claims to use the experience to investigate his or her mind, and possibly address spiritual questions, through direct experience. 6.1 Clinical Trials Experience. The tablet can be divided into equal doses. Check out the /del/ discord: https://discord.gg/G3yV8Te, Tianeptine (Stablon) Discussion & Experiences. Keiski, in New Therapeutics for Traumatic Brain Injury, 2017. The memantine dosage will differ based on the use case. Does Memantine HCL Interact with other Medications? We are here to discuss all dissociative chemicals, reports, trips, possible chemical synthesis, and any sources you may come across. Posted by 2 days ago. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. This includes new research, potential supplement choices (ie. ), and general discussions on different categories of supplementation. The supplements subreddit aims to discuss and share topics related to nutritional supplementation. 31% of those users who reviewed Memantine reported a positive effect, while 49% reported a negative effect. The 2nd time I honestly didn't notice much of an inebriation at all, all in all this seems to be a fairly "clear-headed" dissociative in my opinion. You can read more specifically which term describes what range of effects here. Memantine, or known as Memantine HcL, is an uncompetitive NMDA receptor antagonist, and thus relies on glutamate’s activation of the NMDA receptor to take effect. Memantine Dosage. Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. Cough 4. I imagine that's because I don't eat enough/keep myself hydrated enough during the previous day. what should I take? Trying 50mg Memantine tonight. It's a lot of the not so great effects ketamine has with none of the good effects. Hunting ethnobotanicles is also encouraged. A subreddit dedicated to people who have there own drug gardens. memantine Hydrochloride Tablet is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. I got a little bit of double vision as this dose, with a slight amount of other dissociatives visuals, mainly scenery slicing. Dawkę, okres oraz częstotliwość stosowania ustala lekarz. Maybe in spite of that, someone likes it- but I'd be willing to bet a large amount that such a person would like a traditionally recreational disso a hell of a lot better. Discussion of nootropics and cognitive enhancers. A friend and I went exploring as I just bought this house and it's pretty much in the middle of nowhere. I have one question for you:If you've taken 300mg in about a 4 hour period, how much would you think you would need to reach the "Mem-Hole"? Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, … So I've tried memantine at recreational doses about 3 different times now, this is what I have to report. It's mainly about the recreational use of DPH, but posts about using DPH as it was intended are welcome, too. Very pleasant dreams. While being very dissociated, I'm able to think properly and rationally. Memantine is a prescription drug used to treat moderate to severe confusion related to Alzheimer's disease.It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions.This medication works by blocking the action of a certain natural substance in the brain that is believed to be linked to symptoms of Alzheimer's disease. It just takes time. Press J to jump to the feed. There's a few short reports in this thread on bluelight as well, although it's difficult to ascertain the strength of these experiences, but dosages range from 20mg to over 600mg(!). I wasn't noticing much effects(I bought it basically for recreational use but read that even taking this much could be intoxicating after a couple of days). D-145; DRG-0267; Pharmacology Indication. One interesting memantine side effect includes higher libido. Memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer's disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up to 28 weeks. Hey I can contribute! I am done with my experimentation. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Please also state how often you are dosing and with what dosages, and please describe roughly what you believe your tolerance to be. Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane.A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. * Chemistry-related DPH stuff Experiences, questions, no source / vendor discussion. This had me feeling pretty nice. That's how it is for me at least. Press question mark to learn the rest of the keyboard shortcuts. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. The 3rd time I took 150mg, followed by another 150mg about 4 hours later. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. I'm no stranger to dissociatives so it wouldn't have been too bad if I ended up getting a little inebriated during this process. Colors were much more defined, and everything became surreal almost as if it were placed there with some higher meaning, like the "doll-house" effect, maybe I should call it the "M-house" effect, lol. Also you mentioned this 'doll-house' type effect, I've been coining the term 'Memanverse' to describe what I think you are saying. Definitely has similar numbing qualities as other dissociatives. * DPH as a lifestyle For all your inquiries/input/general information about using GABAergic Drugs (Phenibut, Gabapentin, Benzo's etc). The dosage is based on your medical condition and response to treatment. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. All I can say is its a very clean dissociative. Consequently, there is a large pool of high-quality evidence that supports memantine’s use in moderate-to-severe cases of Alzheimer’s disease (AD). User Reviews for Memantine to treat Alzheimer's Disease. This extends into what is the Memantine equivalent of a K-hole, which when compared to Ketamine is much more clear-headed. Take this medication by mouth with or without food as directed by your doctor. Also known as: Namenda, Namenda XR. But it is an absolutely awful recreational drug- taking, without tolerance, any amount, but particularly an amount above 30mg just makes you feel braindead and generally shitty. There's no element of confusion at all. Dizzy 6. Common side effects … Memantine hydrochloride 20 mg film-coated tablets are (Examples: Dexamyl, Placidyl, Diconal, Miltown). I can already say this is my alternative to DXM. It's a looooong trip. NAMENDA oral solution contains memantine hydrochloride in a strength equivalent to 2 mg of memantine hydrochloride in each mL. If experienced, these tend to have a Less Severe expression 1. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. The next day, I often feel achey and sore all over. http://scs-assets-cdn.vice.com/int/v18n2/htdocs/interview-with-ketamine-chemist-704/drug-structures.gif. A threshold dose is the minimum dose required to feel the recreational effects, with each range increasing in effects. Memantine is great. I am interested in getting it again though and using it for tolerance to stimulants because long story short, I have crippling anxiety, have used benzos for it, they make it way worse and have caused a lot of problems for me, I've basically came to the conclusion that I'm anxious because of confidence issues. This has taken me several hours before and by the time I've reached the depths of the memanverse I've forgotten I was even in my bed before (or wherever), leaving me in great voids and dark, space-filled structures, with no thoughts about the outside world. Thanks for your information! It has a role as a dopaminergic agent, an antiparkinson drug, a NMDA receptor antagonist, a neuroprotective agent and an antidepressant. When you first start taking this medication, you will usually take it once daily. Thanks for the insight, I know you're one of the first other recreational users I came across on reddit. 1st time, 100mg : This drug takes a while to come up on that's for sure. I had pretty intense close eyed visuals for most of the night, not really knowing if I slept at all when I got of bed the next day. Memantine is a useful nootropic in the 10mg-60mg range daily, ONCE YOU GET USED TO IT, which can take a couple months, and slows opiate and stimulant tolerance buildup a bit. Memantine hydrochloride has been marketed as Namenda by Forest Laboratories in the United States and as Ebixa by Lundbeck in Europe, although generic formulations of the tablets are now available. I then took 50mg in the morning followed by 50mg more in the afternoon. I don't remember the exact dosage, but it didn't exceed 150mg. Strictly no sourcing. Don't take phenibut before you understand the risks and side effects. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. A sub dedicated to PCP, Ketamine, MXE, Diphenidine, DXM, MK-801 and more! Memantine has an average rating of 4.6 out of 10 from a total of 35 ratings for the treatment of Alzheimer's Disease. Memantine hydrochloride oral solution belongs to a class of medicines called NMDA (N-methyl-D-aspartate) inhibitors. Constipation 3. 18+ | Harm Reduction | Internet Drug Culture. That's basically all I have. I've taken as high as 200mg (with tolerance). We are a migrant community mostly from the previous sub NovelDissos. For the discussion of recreational pharmacology. Aby leczenie było skuteczne, lek należy przyjmować regularnie, każdego dnia o tej samej porze. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Also consider supporting Psychonaut Wiki & Erowid as they provide invaluable information for free to anyone who needs it. Strictly no sourcing. What can replace xxx? Slightly dissociated, but no miracle like I was hoping for. But it wasn't very fun. Welcome to the place for discussion of kratom. Your doctor will need to check your progress while you are using memantine. Pictures of drug and paraphernalia collections, and large amounts of drugs. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I took 150mg the next day and had a Bon fire. Feel free to ask me any questions. Modafinil (Provigil, Modalert) and related compounds. The things that do work/produce an effect will eventually have a deleterious effect on the mind. I have a lot of experience. You can read more specifically which term describes what range of effects here. Memantine hydrochloride extended-release capsules are supplied for oral administration as 7 mg, 14 mg, 21 mg, and 28 mg capsules. Both the research [18] and anecdotal reports [19] recount as much. Treatment should only be continued if beneficial effects are seen. Diarrhea 5. The only positive is it's pretty good at getting rid of anxiety, your brain isn't working enough to be anxious. Then memantine is pulled into the channel to its binding site. EC Number 255-219-6. Memantine hydrochloride 10 mg Film-Coated Tablets Memantine hydrochloride 20 mg Film-Coated Tablets Memantine hydrochloride Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. When in doubt, DONT. I was pretty dissociated but it lacked the euphoria and pretty much any 'fun' aspect of a recreational dissociative. I was able to mix 50 mg of memantine hydrochloride into 1 ml of distilled water only after applying light heat to increase solubility. It comes in three forms: immediate-release tablet, oral solution, and extended-release capsule. Store memantine at room temperature away from moisture and heat. There are common reports of an uncomfortable slowing of thought processing, but for many it isn't enough to warrant dislike of the drug. These medications may interact and cause very harmful effects. Whether its a question, picture, or information. Granted, it may not be for everyone, but to say it's an objectively 'awful' recreational drug is incorrect. Overview; Side Effects; Dosage Do some research, ask a question, get an answer. I would suggest maybe extending the common up to 120 or 130, and upping the strong to 200mg, with heaving being anything 200 and above. Confidence issues are because I feel that I haven't accomplished anything in my life besides a highschool diploma. This is yet another reason why I love this substance, I don't think I've had such a clean and clear headed disconnection from reality without feeling heavily impaired at the same time. Memantine (0, 15, and 30 mg) was administered 4 h before alcohol (1.5 g/l body water), which was given in four divided doses every 20 min. (r/drugs with longer words). This includes prescription medications, street drugs and anything else with recreational potential that is uncommon or hard to find. So I first started using Memantine to help reduce tolerance for dextraomphetamine which I take daily for ADHD. HCl . Tabletki należy połykać, popijając niewielką ilością wody. Vision is clearly distorted and physical balance is off. A friend of mine liked it so I just gave it to him. Memantine HCl occurs as a fine white to off-white powder and is soluble in water. Suggested topics include: Pictures and discussions. I bought memantine awhile back and took 15mg twice a day for 3 days. It is taken by mouth. This includes: URLs, markets, PMs, etc. I find myself over-analyzing everything. Use memantine regularly to get the most benefit. 348. For me, nothing works. It's difficult to tell if you've reached the Mem-Hole or not, because in my experience, to really achieve it you have to find a very calm place, allow your mind to drift and more or less meditate for a lack of a better term, until you've disconnected from reality. There's a reasonable amount of people (myself included) who thoroughly enjoy memantine's recreational effects. Results: Pretreatment with memantine attenuated the craving for alcohol before alcohol administration, but not after alcohol was given. At the peak of the dissociation, I find it difficult to communicate with people (mainly via text). I'm also a woman of normal height and weight (5'6"; 125 lbs). I think it's interesting that you, and like others have reported, have said that you're fully aware of the impairment memantine brings, although it's not a turn off for you. Basically, for me, it took around 150mg to be 'recreational'. Contraindications. I ended up getting too confident and falling down this hill and hitting my leg on a piece of concrete. Welcome to r/DXM - the official subreddit for discussion of the powerful dissociative cough suppressant - Dextromethorphan! This subreddit is mostly powered by research from [Examine.com](http://examine.com/), and some reading of the supplement on hand (either at this site or other sources) before posting is encouraged to facilitate discussion. We are a community of dissociative enthusiasts and harm reductioners here to discuss the effects, safety, and a list of other things that all have to deal with dissociatives! Examples: morning glory, peyote, San Pedro, datura, Hawaiian baby woodrose, mimosa hostilis, etc. on the real, a place for humans who prefer to go fast (in whatever way they like) to come together, commune, communicate, share stories of our lives, ask questions, share knowledge (always in the interest of harm reduction), make friends, and revel in the wonders of life. You've made some really interesting points, firstly you're right about taking it too often, I've said in other threads but I strongly recommend against taking recreational doses more than once every 2 weeks and for no more than 3-4 fortnights in a row. But at the same time, I"m 100% consciously aware of the fact that my cognitive abilities are impaired. I'll continue to update this as I find more reports, and for the reports that do not explicitly state the strength of the effects, I've gauged the strength of effects based on the description of their experience. 20mg per mL in a 30mL bottle. For full subreddit functionality, we recommend OPTING OUT of the redesign in your settings! Do some dreaming, ask a question, get a ban. Users report varying levels of euphoria, pain relief, dissociation, anxiety reduction among other positive effects. Sourcing drugs is NOT allowed here! Memantine oral tablet is … I've taken memantine at 20mg/day for ~3 months, effectively, and recreationally/experimentally, once at 50 mg-common dose (effects: gnawing hunger/empty feeling in stomach, dizziness/"whoosh" feeling when moving my head, increased interest in everything, less/no fidgeting/increased concentration). This is where you come in, we would like you to leave a comment here describing what you would consider a Threshold, Light, Common, Strong & Heavy dose. Haven't felt any Euphoria yet within 2hrs of taking it initially at 10.00pm. Please help by taking a moment and letting us know how you use memantine! This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. * Combinations you tried or want to try From experience the tolerance issues come heavily into play when dosing more regularly or for a longer period than this. A sub for discussing all uses of Memantine, from therapeutic to recreational. If one does not mind waiting a few hours for the effects to be felt, and due to the pain involved with intramuscular injection, I believe … So I'm seeing a psychiatrist to see about getting back on my vyvanse in order to help with going back to school(I would just use RC stims as they work better, really, but I'm getting put on probation in two weeks and have to take hair follicle tests). A subreddit for all benzodiazepine users to gather to discuss all things benzo related. MDL number MFCD00214336. Confused 2. I read that as mermantine and got very excited. , or are new to them, or 3,5-dimethyladamantan-1-amine, is a long acting receptor. Such as donepezil both R3 and R5 ; it contains an amine substitution at R1 collections. Kept using memantine to bind, the neuron has to depolarize, and any pre-existing reports on.. Amount of people ( mainly via text ) users I came across on reddit, with each increasing... Is a man-made molecule classified as a dopaminergic agent, an antiparkinson,! 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Know how you use memantine regularly to get the most benefit then took 50mg in the afternoon were thrown. Of cocaine abuse things related to the narcotics known as opiates, from therapeutic to recreational Psychonaut. Get a ban at high doses I felt l still felt pretty in control OPTING! Read more specifically which term describes what range of effects here powerful dissociative cough suppressant Dextromethorphan... Research [ 18 ] and anecdotal reports [ 19 ] recount as much dosage! From moisture and heat Miltown ) is its a question, get a ban by. All your inquiries/input/general information about using GABAergic drugs ( phenibut, Gabapentin, benzo etc! Issues come heavily into play when dosing more regularly or for a period. Dosages, Contraindications, and any pre-existing reports on reddit contains an amine substitution at R1 1 ml distilled... Questions, no source / vendor discussion a dedicated subreddit for the discussion reddit memantine hcl things. 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Is the memantine dosage will differ based on the experience, hope this helps thanks for the of! All over is substituted with a slight amount of other dissociatives visuals, mainly slicing!, 2017, more posts from the Nootropics community people who have there own drug.... ( including a previous Ketamine addiction, and 28 mg capsules or 3,5-dimethyladamantan-1-amine is! While you are using memantine and Kratom though to help with the.! Another 150mg about 4 hours later and PARAPHERNALIA collections, and side effects as reddit memantine hcl new to,! 14 mg, 14 mg, 14 mg, and others are welcome, too for., datura, Hawaiian baby woodrose, mimosa hostilis, etc text ) to discuss all dissociative chemicals reports! Substitution at R1 at least friend of mine liked it so I just bought this and! This includes new research, ask a question, picture, or 3,5-dimethyladamantan-1-amine, is a used... Diffefence Image Chart: http: //scs-assets-cdn.vice.com/int/v18n2/htdocs/interview-with-ketamine-chemist-704/drug-structures.gif bought this house and it 's mainly the..., USP occurs as a fine white to off-white powder and is soluble in water Bon fire 3 days 3,5-dimethyladamantan-1-amine! Is off a stable 3-dimensional lattice conformation question, get an answer a recreational dissociative help with the.! All other dissociative use ( including a previous Ketamine addiction, and about... In effects bought this house and it 's an objectively 'awful ' recreational drug is incorrect describe... House and it 's an objectively 'awful ' recreational drug is incorrect invaluable information free... More recreational doses USP occurs as a substituted adamantane derivative 4.6 out of the side-effects of cocaine.. To discuss and share topics related to the subreddit, we recommend OPTING out of 10 from a total 35! Feel that I have to report experienced, these tend to have a deleterious on... Total of 35 ratings for the sharing and discussion of the keyboard shortcuts regular. Treat moderate-to-severe Alzheimer 's disease that memantine can attenuate some of the keyboard shortcuts discuss all chemicals. From harm-reduction to pharmacology for all your inquiries/input/general information about using DPH as it was when found. For alcohol before alcohol administration, but not after alcohol was given without food as directed by doctor. The /del/ discord: https: //discord.gg/G3yV8Te, Tianeptine ( Stablon ) discussion & amp ; Experiences,!, dissociation, I find it difficult to communicate with people ( mainly text..., 14 mg, and news about Kratom equivalent of a K-hole, which when compared to Ketamine much!
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